Dr Kinan Mokbel

Academic Lecturer in Clinical Pharmacy & Clinical Research Fellow

Dr. Kinan Mokbel is a pharmacist who provided healthcare services and contributed to research for 18 years. As an educator, he has taught academic modules to undergraduates, postgraduates, and registered community pharmacists. Kinan is the lead for the following modules in both the MSc Clinical Pharmacy and MSc Advanced Clinical Practice programmes:

• Long-Term Condition Care (Respiratory, Endocrine and Renal)
• Long-Term Condition Care (Cardiovascular)

Kinan is also the Clinical Research Fellow for the ERASE-LC study where he is the primary patient contact. He coordinates the safe administration of various clinical assessments and ensures that the patients receive professional care whilst participating in the clinical trial.

Additionally, Kinan completed a Postdoctoral Research Fellowship in the Department of Health and Community Sciences as part of the Spotting Cancer among Comorbidities (SPOCC) programme team. Within the SPOCC programme, Kinan conducts research on patient help-seeking behaviours and/or how GPs/nurses identify potential symptoms of cancer. This NIHR-funded initiative, led by the APEx Team at the University of Exeter in collaboration with University College London, aims to understand how pre-existing medical conditions increase the risk of a delayed cancer diagnosis. The ultimate goal is to leverage this information to enhance cancer diagnosis and improve survival rates.

Kinan holds an honorary senior research fellowship at the London Breast Institute in the Princess Grace Hospital, London, since 2016. In this role, he collaborates with a multidisciplinary team on research related to the influence of genetics on treatment response and the development of new breast cancer drugs.

Qualifications

• Master of Pharmacy
• Post-graduate Certificate in Pharmacy Education Development
• Master of Science in Clinical Pharmacy
• Master of Science in Genomic Medicine
• PhD - Pharmacogenomics of Medically Important Adverse Drug Effects
• ASPIRE Higher Education Academy Associate Fellowship
• Fellow of the Higher Education Academy (FHEA)

Research projects

• ERASE – long COVID (Clinical feasibility study of the efficacy of Remdesivir for long COVID)
• SPOCC: SPOtting Cancer among Comorbidities.
• Pharmacogenomics of Medically Important Adverse Drug Effects. Learn about genomic medicine and pharmacy practice.
• Assessing the prevalence of genotypes conferring risk of severe adverse drug reactions in participants of UK Biobank. Learn about Genomics for Pharmacy and its significance in pharmacy practice.

Research group links

• Exeter Collaboration for Academic Primary Care (APEx)
• ERASE – long COVID (Clinical feasibility study of the efficacy of Remdesivir for long COVID)

Research interests

• Spotting cancer among comorbidities and supporting clinical decision-making in patients with symptoms of cancer and pre-existing conditions.
• Safety of medicines in general practice.
• The role of community pharmacists in addressing adverse drug effects.
• Genomic profiling scores for chemotherapy recommendations in women with breast cancer.
• Prognostication tools in the context of adjuvant treatment of early breast cancer.
• Long COVID
• Genetic testing in clinical practice.
• Chemoprevention of breast and prostate cancers with vitamins and micronutrients.

Conferences

The Clinical Pharmacy Congress 10-11 May 2024, London, England. The Impact of the COVID-19 Pandemic on Medication Prescribing Patterns in General Practice: A Retrospective Time-trend Analysis. Abstract.

The Clinical Pharmacy Congress North 3-4 November 2023, Manchester, England. A Nationwide Comparative Safety Study of Medicines Within the Therapeutic Class: A Novel Data Integration Approach Based on the Yellow Card Reporting Scheme and the English General Practice Prescription Data. Abstract.

The 7th International Congress of the European Society for Pharmacogenomics and Personalised Therapy (ESPT), October 25-27th, 2023, Copenhagen, Denmark. Pharmacogenomic Variants of Medically Important Adverse Effects Related to High-Risk Medicines in General Practice Can Not Be Replicated in UK Biobank. Abstract.

The 16th Annual Meeting of Korean Society of Medical Oncology & 2023 International Conference & 11th International FACO Conference, September 7th to 8th 2023, Seoul, Korea. Pharmacogenetics of Endocrine Therapy Associated Toxicities in Breast Cancer. Author URL.

The European Society of Human Genetics Conference, June 10–13th, 2023, Glasgow, Scotland, UK. The Majority of Pharmacogenomic Variants Associated with Adverse Drug Events When Taking Endocrine Therapies for Breast Cancer Can Not Be Replicated in UK Biobank Participants. Author URL.

The Association for Cancer Surgery Annual Scientific Conference and the NCRI Cancer Conference 5th–8th November 2017 Liverpool, UK. A comparison of the performance of EndoPredict Clinical and NHS PREDICT in 120 patients treated for ER+ breast cancer. Author URL.

Key Publications

A Comparative Safety Analysis of Medicines Based on the UK Pharmacovigilance and General Practice Prescribing Data in England. URL. PDF.

Pharmacogenomic Determinants of Adverse Drug Effects: A Systematic Review and Meta-analysis. URL. PDF.

The Role of Community Pharmacists in Addressing Medication-related Issues for Breast Cancer Patients Receiving Adjuvant Endocrine Therapy. URL. PDF.

A Time-Varying Analysis of General Practice Prescribing in the COVID-19 Era: Lessons from Prescription Dynamics in a Pandemic (In Press).

Pharmacogenetics of Toxicities Related to Endocrine Treatment in Breast Cancer: A Systematic Review and Meta-Analysis. URL. PDF.

Chest Pain at Rest with Unremarkable ECG and Cardiac Enzymes: Case Study Emphasising the Importance of Clinical Suspicion in Diagnosis of Coronary Artery Disease (In Press).

Bone Mineral Density, Bone Biomarkers, and Joints in Acute, Post, and Long COVID-19: A Systematic Review. URL. PDF.

Heart Failure Masked as Pulmonary Embolism in Non-Adherent Patient with Atrial Fibrillation: Case Report and Analytical Review of the Literature (In Press).

Lower Limb Chronic Ischaemia Presenting Exclusively as Fungal Toenail Infection: Case Report and Brief Literature Review. URL. PDF.

Reevaluating Axillary Lymph Node Dissection in Total Mastectomy for Low Axillary Burden Breast Cancer: Insights from a Meta-Analysis including the SINODAR-ONE Trial. URL. PDF.

Transient Ischaemic Attack in a Patient with Conn Syndrome: A Case Report and Literature Review on the Importance of Identifying Secondary Hypertension (In Press).

Pre-pectoral Immediate Breast Reconstruction Following Conservative Mastectomy Using Acellular Dermal Matrix and Semi-smooth Implants. URL. PDF.

Omitting Sentinel Lymph Node Biopsy After Neoadjuvant Systemic Therapy for Clinically Node Negative HER2 Positive and Triple Negative Breast Cancer: A Pooled Analysis. URL. PDF.

Do online prognostication tools represent a valid alternative to genomic profiling in the context of adjuvant treatment of early breast cancer? A systematic review of the literature. URL. PDF.

A Comparison of the Performance of EndoPredict Clinical and NHS PREDICT in 120 Patients Treated for ER-positive Breast Cancer. URL. PDF.

Wire-Free Targeted Axillary Dissection: A Pooled Analysis of 1300+ Cases Post-Neoadjuvant Systemic Therapy in Node-Positive Early Breast Cancer. URL. PDF.

Are online prediction tools a valid alternative to genomic profiling in the context of systemic treatment of ER-positive breast cancer? URL. PDF.

The Impact of EndoPredict Clinical Score on Chemotherapy Recommendations in Women with Invasive ER+/HER2- Breast Cancer Stratified as Having Moderate or Poor Prognosis by Nottingham Prognostic Index. URL. PDF.

Evaluating Magnetic Seed Localization in Targeted Axillary Dissection for Node-Positive Early Breast Cancer Patients Receiving Neoadjuvant Systemic Therapy: A Comprehensive Review and Pooled Analysis. URL. PDF.

Chemoprevention of Breast Cancer with Vitamins and Micronutrients: A Concise Review. URL. PDF.

Harnessing Micronutrient Power: Vitamins, Antioxidants, and Probiotics in Breast Cancer Prevention. URL. PDF.

Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies. URL. PDF.

Does CYP2D6 Genotyping Have a Role in Guiding Tamoxifen Therapy? URL. PDF.

CRISPR/Cas9-Mediated Genome Nano-Surgery: An Update. URL. PDF.

Genetic testing in clinical practice: An ethical perspective. PDF.

The Intrinsic Pathway of Apoptosis and Carcinogenesis: An Update. URL. PDF.

Manuscripts under consideration

Chronic Kidney Disease Following Cardiac Arrest Manifesting as Dyspnoea and Peripheral Oedema in Cardiovascular Multimorbidity: Case Analysis and Brief Literature Review.

Association between Genomic Variants and Medically Important Adverse Drug Effects Related to High-Risk Medications in General Practice in Participants in UK Biobank.

Endocrine Therapy and Medically Important Adverse Drug Effects: A Pharmacogenomic Investigation in Breast Cancer Patients in UK Biobank.